Dr. Gregory Mathien was born in Buffalo, New York, and attended State University of New York in Syracuse for both his undergraduate and medical degrees. He remained in Syracuse to complete his surgical internship and orthopaedic surgery residency.

In 1991, Dr. Mathien came to Knoxville for the Sports Medicine Fellowship under the direction of Dr. William T. Youmans. During his fellowship, KOC recruited him to remain as a KOC surgeon and help expand the KOC sports medicine program, enhancing the care of injured athletes. This has evolved into an extensive program placing certified athletic trainers in Knox County high schools. In developing this program he received the Tennessee Interscholastic Athletic Administrators Association Distinguished Service Award in 2011.

Dr. Mathien currently serves as the Senior Team Orthopaedic Surgeon for the University of Tennessee athletic programs. The University of Tennessee Lettermen's "T" Club has given him Honorary Membership status. 

Dr. Mathien has served as a consultant for the Tennessee Smokies, the Knoxville Ice Bears and Lincoln Memorial University athletics. He has also operated on and cared for many Olympic medalists and professional athletes. He plays an active role in national sports medicine research, including the Multicenter ACL Revision Study.

Dr. Mathien is board certified by the American Board of Orthopaedic Surgery in sports medicine and is a member of the American Orthopaedic Society for Sports Medicine and the American Academy of Orthopaedic Surgeons.

He and his wife, Clara, live in Knoxville. They have two children, Zachary and Rebecca, along with their Labrador retrievers. They are active in their church and community activities.




Contact Information

Office Info KOC: 865-558-4400
Appointments: 865-558-4444
Office Location

Old Weisgarber Road
Fort Sanders West
North Knoxville

Administrative Assistant


865-558-4425 or internal ext 4425

865-244-3027 or internal ext 4637


Dr. Mathien's Videos



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What patients say about Dr. mathien

  • Thanks to my care at KOC, I can do the same outdoor activities that I did before my accident. I had fallen off of a piece of farm equipment in May of 2019 and thought I had permanently damaged my "wheels." I am an avid backpacker, park service volunteer, hunter and part time farmer. A friend of mine recommended that I see Dr. Mathien about repairing my knee after my "one second of stupidity." I was 60 years old when I had the accident. Dr. Mathien decided that I was healthy enough to repair my meniscus which according to my physical therapist I was too "old" for such a procedure. Thanks to the expertise and confidence Dr. Mathien had in his abilities the surgery was a success. There was some work on my part to recover but without his steady hand I don't think I would have been able to do what I do today. I continue to hunt and in October of 2020 I completed an 8 mile very rugged backpacking trip with a fully loaded backpack that weighed in excess of 40 pounds. Thanks, Dr. Mathien for your confidence in me and more importantly yourself. I am very grateful!!!
    – Ray, Monterey
  • 20 years ago, I had an ACL reconstruction done by my KOC partner, Dr. Greg Mathien. Three weeks prior, I was playing church league basketball (at age 37) and landed after an otherwise innocent rebound and felt a strange thunk in my left knee. Everybody else thought I had rolled my ankle. I knew it was different (I am a pediatric orthopedist at KOC). Three days later, I let myself accept the truth and let Dr. Mathien examine my knee. He was calm and talkative as he manipulated my knee, but then said, “Oh yeah. Your ACL is gone.” Three weeks of working out the stiffness and weakness and then day of surgery. I had complete faith and trust in him and all went well. Therapy at KOC started three days later. I was back to work in a week. I was riding a 60 mile bike ride 3 months later, and skiing with college buddies the next winter. I have played with my kids (now all grown), done dozens of triathlons, and gone on many multi-day bike trips for my birthday since then and never had a hint of problem with my knee. Thank you, Dr. Mathien, for letting me push back middle age a couple decades (and counting).
    – Cameron, Knoxville
  • Dr. Mathien is a very caring and listens to you and gives detailed feedback and answers your questions. Great surgeon who has practiced for many years and has tons of knowledge I couldn't be happier with him and his nursing staff. I hurt my knee after surgery and they were quick to get me back in to see him.
    – Nancy, Knoxville
  • Thanks to my care at KOC, I can fight cancer. In November 1998, I tore my left ACL playing intramural flag football. I was a freshman at UT and it was my first time really being away from home. When I went to the Student Health Center, they referred me to Dr. Mathien. He was so kind and reassuring. He told me about my ACL tear and set me up for surgery. He gave me clear instructions for my recovery and held me accountable. He did such excellent work that I returned to all my normal activities and haven't had any problems since. Perhaps most importantly, though, he inspired me to consider surgery as a career.
    I came from a very small town and never even considered that I might be able to become a surgeon. But, I thought it was such a miracle that he was able to fix my knee and I could return to the sports and the active lifestyle I enjoyed. Not only did he inspire me, but he also inspired my twin sister, Lydia, who came to every appointment with me. We both went on to attend Vanderbilt Medical School with full scholarships, where our love of the operating room was confirmed. Lydia went on to become an orthopedic surgeon. She completed her fellowship at the Andrews Institute not too long ago. I was called into General Surgery and I now have a practice in Murfreesboro, TN. The majority of my practice involves taking care of breast cancer patients. As I take care of these women, I think about Dr. Mathien and all the lives he has touched, without even knowing it.
    My left knee remains as good as new. I've run two half marathons, ride horses all the time, hike, and travel all over the world without any problems. I just wanted to thank Dr. Mathien and KOC for all you've done for me.
    – Lisa, Murfreesboro
  • Thanks to my care at KOC, I can continue to actively participate in lacrosse and ice hockey at the age of 54. Dr. Mathien operated on both of my knees. He repaired my ACL, MCL and meniscus in my right knee, then repaired a chipped bone and possible infection in my left knee due to an accident. He was wonderful and caring and I would highly recommend him to anyone.
    – Ed, Knoxville
  • My 11-year-old grandson plays outfield and pitches on a travel baseball team. He was experiencing some pain in his elbow and then got an injury to that same elbow. Dr. Mathien treated him, which included taking him out of baseball for several weeks. My grandson was very upset, but Dr. Mathien was excellent in handling this. He speaks directly to the patient in a manner they can understand and shows great respect and understanding. Each time we were there, he took that extra moment to give him a "little life lesson." Not only is Dr. Greg Mathien an excellent physician, he is great person!
    – Nina, Knoxville
  • Thanks to my care at KOC, I can walk with no pain in my knee. Sometimes, the best treatment a doctor can give you is to deny your request.

    I saw Dr. Mathien for the first time on April 7, 2016. After looking at my x-rays, he told me that my arthritic knees would probably need to be replaced at some point. Here's the catch - at 58 years old, I weighed 305 pounds (a BMI of 41) and I had all the co-morbid conditions that go with that - high blood pressure, hyperlipidemia, type 2 diabetes, etc. He told me that I was not a good candidate for surgery. I had "backed myself into a corner," he said, and my best course of action was to have bariatric surgery.

    I left the office mad and in a foul mood. I wasn't mad at Dr. Mathien (well, maybe a little). I was mad, humiliated, and embarrassed that I had let myself get into such bad shape. After stewing for a few hours, I made up my mind to take care of my situation. I did not have bariatric surgery because my insurance would not cover the procedure. I did, however, work with my family doctor, and over the next 174 days I lost 110 pounds. Along with that, my blood pressure, lipids, and average blood glucose levels all returned to normal levels. On November 8, 2016, I weighed 188 pounds (a total loss of 117 pounds), which made my BMI 24.9, i.e., normal.

    I returned to see Dr. Mathien in October of 2016. He informed me that I had earned the right to take the next step. I took that next step when, on November 8, 2016, Dr. Mathien performed total knee replacement surgery on my right knee. Now, 14 weeks after surgery, I am back to a high level of activity, but with no pain in my knee.

    I thank God for putting Dr. Mathien in my life at that time. I'm thankful that he cared enough to talk straight with me and tell me what I needed to hear. He didn't tell me anything I didn't already know, but somehow hearing it out loud made it real and made me give it the attention it deserved.

    I'm also thankful for the skill and expertise he used when he performed my surgery. The operation was a total success, and for the first time in about 30 years, I'm pain free in my right knee.

    I recommend Dr. Mathien without qualification. He is the best. Period.
    – Cliff, Walland


  • B.S., State University of New York, in Association with Syracuse University, 1982
  • M.D., State University of New York Health Science Center, 1986


  • General Surgery, State University of New York Health Science Center, 1987


  • Orthopaedic Surgery, State University of New York Health Science Center, 1991


  • Sports Medicine, Knoxville Orthopaedic Clinic, 1992

Began Practice At KOC

  • 1992

Board Certification

  • American Board of Orthopaedic Surgery - Subspecialty Sports Medicine

Professional Distinctions

  • Adjunct Assistant Professor - The University of Tennessee Exercise Science Unit
  • Orthopaedic Team Physician - The University of Tennessee Athletic Department
  • American Orthopaedic Society for Sports Medicine
  • American College of Sports Medicine
  • American Academy of Orthopaedic Surgeons
  • Wilderness Medical Society


  • ATLS Certified by the American College of Surgeons


  • Sports Medicine and Athletic Injuries
  • Knee Surgery